A leading provider of
innovative DNA Screening solutions
Wolf-Hirschhorn LPU 009
Wolf-Hirschhorn syndrome is a multiple malformation syndrome characterised by severe growth deficiency, severe to profound mental retardation with the onset of convulsions in early infancy, microcephaly, sacral dimples and characteristic face ('Greek helmet appearance') 1.
The phenotype results from the partial deletion of the short arm of chromosome 4 (4p16.3), originally observed as a large cytogenetically visible terminal deletion of 2Mb. Molecular analyses of patients with small terminal and interstitial deletions have allowed for the definition of the Wolf-Hirschhorn Critical Region, which is 165Kb and lies between D4S166 and D4S33272.
References:
- Wilson MG et al., Hum Genet 1981;59:297-307
- Wright TJ et al., Hum Mol Genet 1997;6(2):317-24
Wolf-Hirschhorn
Cat. No. LPU 009-S (5 tests)
Cat. No. LPU 009 (10 tests)
This webpage could contain information on product details or information not valid in your country or region. Please be aware that we do not take any responsibility for accessing such information, which may not comply with any legal process, regulation, registration or usage in the country of your origin. If you are a resident of a country other than those to which this site is directed, contact your local Cytocell distributor to obtain the appropriate product information for your country of residence.
Developed &produced in the UK