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AML1 Breakapart LPH 027
The AML1 (CBFA2 or RUNX1) gene is the most frequent target of chromosomal rearrangements observed in human acute leukaemia. The most common rearrangements are the TEL/AML1 and AML1/ETO fusions which provide for a favourable outcome whilst the TEL/AML1 fusion is associated with late relapse.
The AML1 gene is also involved in many other rare translocations including the partner chromosomes - 1, 2, 3, 4, 6, 9, 16, 20 and X. AML1 has also been found amplified in childhood ALL and is associated with a poorer outcome.
AML1 Breakapart
Cat. No. LPH 027-S (5 tests)
Cat. No. LPH 027 (10 tests)
- AML
- ALL
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