IGL Breakapart LPH 033 - Detail

Translocations involving the immunoglobulin loci are recurring events in various subtypes of B-cell lymphomas.

In addition to translocations involving the IGH locus, variant translocations have been described in 5-10% of B-cell neoplasms involving either the immunoglobulin kappa (IGK) light chain locus at 2p11.2 or the lambda light chain (IGL) at 22q11^1,2. The best known translocations involving IG light chain loci are the variant Burkitt's translocations t(2;8)(p12;q24) and t(8;22)(q24;q11) present in up to 25% of all Burkitt's lymphomas³. Other translocations involve the BCL6 oncogene: the t(2;3)(p12;q27) and t(3;22)(q27;q11) and BCL2 locus: t(2;18)(p12;q21) and t(18;22)(q21;q11)^4,5.

Translocations involving the IG light chain loci usually lead to breakage within the joining region of the respective locus². IGL consists of 38 potentially active variable (IGLV) gene segments, 35 pseudogenes and seven IGL constant gene segments, each with a joining (J)-segment IGL (J-C).

References:

1. Poulseu TS et al., Leukemia 2002;16:2148-55
2. Martin-Subero JI et al., Int J Cancer 2002;98:470-4
3. Kornblau SM et al., Hematol Oncol 1991;9:63-78
4. Chaganti SR et al., Genes Chromosomes Cancer 1998;23:323-7
5. Tashiro S et al., Oncogene 1992;7:573-7