A leading provider of
innovative DNA Screening solutions
As long ago as the 19th Century, nuclear changes were recognised as being significant in cancer biology. Advances in cytogenetics and molecular cytogenetics in the last century showed that although a number of numerical and structural chromosome changes appeared to be random and non-specific, rearrangements involving individual chromosomes were shown to define specific abnormalities in individual tumour types.
Fluorescence In Situ Hybridisation (FISH) using locus-specific probes which are capable of defining these stereotypic structural rearrangements has now become a routine diagnostic test in the clinical laboratory. The technique has thus been shown to be useful in the management of cancer patients.
Cytocell offers a range of FISH probes specific for a number of haematological malignancies which are available in the Aquarius® liquid format. These probes are directly labelled, ready to use in hybridisation buffer and available in economical 5, and larger 10 test kits. The protocol is rapid and simple and has been developed to allow co-denaturation of the FISH probe and target DNA simultaneously.
The probe mixtures are designed for Fluorescence In Situ Hybridisation of interphase cells and metaphase chromosomes from cultured peripheral blood cells or cultured bone marrow samples.
myProbes® is a custom FISH probe design and manufacture service, which utilises Cytocell's proprietary BAC clone collection. If a product you require does not appear in the catalogue, do not hesitate to contact Cytocell with your request.
The Chromoprobe Multiprobe® haematology devices are panels made up of 8 squares, with each one containing a prognostically important probe set for the disease. They are designed to detect multiple rearrangements that occur in ALL; CLL and low grade lymphoma; AML and MDS . These can be used to rapidly determine genotype in leukaemia patients and aid in prognosis and future treatment decisions.
5 and 10 tests
Supplied with DAPI counterstain and full instructions for use
Which condition is associated with which FISH probe? Use our handy haematology key to find out. Look for the key on each haematology product.
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